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Cardiac Phosphodiesterases and their Modulation for Treating Heart Disease

An important hallmark of cardiac failure is abnormal second messenger signaling due to impaired synthesis and catabolism of adenosine 3’,5’-cyclic monophosphate (cAMP) and cyclic guanosine 3’,5’-cyclic monophosphate (cGMP). Their dysregulation, altered intracellular targeting, and blunted responsive...

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Detalhes bibliográficos
Publicado no:Handb Exp Pharmacol
Main Authors: Kim, Grace E., Kass, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665023/
https://ncbi.nlm.nih.gov/pubmed/27787716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/164_2016_82
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