A Dual Role of P53 in Regulating Colistin-Induced Autophagy in PC-12 Cells

This study aimed to investigate the mechanism of p53 in regulating colistin-induced autophagy in PC-12 cells. Importantly, cells were treated with 125 μg/ml colistin for 12 and 24 h after transfection with p53 siRNA or recombinant plasmid. The hallmarks of autophagy and apoptosis were examined by re...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Lu, Ziyin, Chen, Chunli, Wu, Zhiyong, Miao, Yusong, Muhammad, Ishfaq, Ding, Liangjun, Tian, Erjie, Hu, Wanjun, Ni, Huilin, Li, Rui, Wang, Bo, Li, Jichang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664992/
https://ncbi.nlm.nih.gov/pubmed/29163157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00768
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