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Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, we build a compendium of 2218 primary tumours across 12 human cancer types and systematically screen for homozygous deletions, aiming to identify rare tumour suppressors. Our analysis defines 96 genomic regions...
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Pubblicato in: | Nat Commun |
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Autori principali: | , , , , , , , , , , , , , , , , , |
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
Nature Publishing Group UK
2017
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5663922/ https://ncbi.nlm.nih.gov/pubmed/29089486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01355-0 |
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