Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, we build a compendium of 2218 primary tumours across 12 human cancer types and systematically screen for homozygous deletions, aiming to identify rare tumour suppressors. Our analysis defines 96 genomic regions...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Cheng, Jiqiu, Demeulemeester, Jonas, Wedge, David C., Vollan, Hans Kristian M., Pitt, Jason J., Russnes, Hege G., Pandey, Bina P., Nilsen, Gro, Nord, Silje, Bignell, Graham R., White, Kevin P., Børresen-Dale, Anne-Lise, Campbell, Peter J., Kristensen, Vessela N., Stratton, Michael R., Lingjærde, Ole Christian, Moreau, Yves, Van Loo, Peter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663922/
https://ncbi.nlm.nih.gov/pubmed/29089486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01355-0
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