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Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation

Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases (KMTs) remain largely elusive. Here, we investigated METTL12, a mitochon...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Małecki, Jędrzej, Jakobsson, Magnus E., Ho, Angela Y. Y., Moen, Anders, Rustan, Arild C., Falnes, Pål Ø.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663892/
https://ncbi.nlm.nih.gov/pubmed/28887308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808451
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