Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with Alzheimer’s disease (AD). Recently, we showed that abnormal levels of Aβ42 in cerebrospinal fluid (CSF) can be detected before abnormal amyloid can be detected using PET in individuals with preclinical AD. U...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Palmqvist, Sebastian, Schöll, Michael, Strandberg, Olof, Mattsson, Niklas, Stomrud, Erik, Zetterberg, Henrik, Blennow, Kaj, Landau, Susan, Jagust, William, Hansson, Oskar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663717/
https://ncbi.nlm.nih.gov/pubmed/29089479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01150-x
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