Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells

Down syndrome (DS) is mostly caused by a trisomy of the entire Chromosome 21 (Trisomy 21, T21). Here, we use SWATH mass spectrometry to quantify protein abundance and protein turnover in fibroblasts from a monozygotic twin pair discordant for T21, and to profile protein expression in 11 unrelated DS...

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Udgivet i:Nat Commun
Main Authors: Liu, Yansheng, Borel, Christelle, Li, Li, Müller, Torsten, Williams, Evan G., Germain, Pierre-Luc, Buljan, Marija, Sajic, Tatjana, Boersema, Paul J., Shao, Wenguang, Faini, Marco, Testa, Giuseppe, Beyer, Andreas, Antonarakis, Stylianos E., Aebersold, Ruedi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663699/
https://ncbi.nlm.nih.gov/pubmed/29089484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01422-6
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