Induction of Peripheral Tolerance in Ongoing Autoimmune Inflammation Requires Interleukin 27 Signaling in Dendritic Cells

Peripheral tolerance to autoantigens is induced via suppression of self-reactive lymphocytes, stimulation of tolerogenic dendritic cells (DCs) and regulatory T (Treg) cells. Interleukin (IL)-27 induces tolerogenic DCs and Treg cells; however, it is not known whether IL-27 is important for tolerance...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Thomé, Rodolfo, Moore, Jason N., Mari, Elisabeth R., Rasouli, Javad, Hwang, Daniel, Yoshimura, Satoshi, Ciric, Bogoljub, Zhang, Guang-Xian, Rostami, Abdolmohamad M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663690/
https://ncbi.nlm.nih.gov/pubmed/29163476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01392
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