DNA hypermethyation and silencing of PITX1 correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is associated with the accumulation of genetic and epigenetic changes in the background mucosa. Dysregulated DNA methylation is known to lead to the inactivation of tumor suppressor genes and the activation of oncogenes. To identify the genes whose expressio...

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Vydáno v:Oncotarget
Hlavní autoři: Otsubo, Takeshi, Yamada, Kazuhiko, Hagiwara, Teruki, Oshima, Kenshiro, Iida, Kei, Nishikata, Koro, Toyoda, Tetsuro, Igari, Toru, Nohara, Kyoko, Yamashita, Satoshi, Hattori, Masahira, Dohi, Taeko, Kawamura, Yuki I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663609/
https://ncbi.nlm.nih.gov/pubmed/29137437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21375
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