Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity

Granulysin (GNLY) is a cytolytic and proinflammatory protein expressed in activated human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Conventional mouse models cannot adequately address the triggering mechanism and immunopathological pathways in GNLY-associated diseases due to lack...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hsiao, Ya-Wen, Lai, Tsung-Ching, Lin, Yu-Hsiang, Su, Chia-Yi, Lee, Jih-Jong, Liao, Albert Taiching, Lin, Yuan-Feng, Hsieh, Shu-Chen, Wu, Alexander T.H., Hsiao, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663531/
https://ncbi.nlm.nih.gov/pubmed/29137359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11473
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