MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

Melanoma can be stratified into unique subtypes based on distinct pathologies. The acral/mucosal melanoma subtype is characterized by aberrant and constitutive activation of the proto-oncogene receptor tyrosine kinase C-KIT, which drives tumorigenesis. Treatment of these melanoma patients with C-KIT...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhan, Yao, Guo, Jun, Yang, William, Goncalves, Christophe, Rzymski, Tomasz, Dreas, Agnieszka, Żyłkiewicz, Eliza, Mikulski, Maciej, Brzózka, Krzysztof, Golas, Aniela, Kong, Yan, Ma, Meng, Huang, Fan, Huor, Bonnie, Guo, Qianyu, da Silva, Sabrina Daniela, Torres, Jose, Cai, Yutian, Topisirovic, Ivan, Su, Jie, Bijian, Krikor, Alaoui-Jamali, Moulay A., Huang, Sidong, Journe, Fabrice, Ghanem, Ghanem E., Miller, Wilson H., del Rincón, Sonia V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663367/
https://ncbi.nlm.nih.gov/pubmed/29035277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91258
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