Clinically resolved psoriatic lesions contain psoriasis-specific IL-17–producing αβ T cell clones

In psoriasis, an IL-17–mediated inflammatory skin disease, skin lesions resolve with therapy, but often recur in the same locations when therapy is discontinued. We propose that residual T cell populations in resolved psoriatic lesions represent the pathogenic T cells of origin in this disease. Util...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Matos, Tiago R., O’Malley, John T., Lowry, Elizabeth L., Hamm, David, Kirsch, Ilan R., Robins, Harlan S., Kupper, Thomas S., Krueger, James G., Clark, Rachael A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663366/
https://ncbi.nlm.nih.gov/pubmed/28945199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93396
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