Hdac3 regulates lymphovenous and lymphatic valve formation

Lymphedema, the most common lymphatic anomaly, involves defective lymphatic valve development; yet the epigenetic modifiers underlying lymphatic valve morphogenesis remain elusive. Here, we showed that during mouse development, the histone-modifying enzyme histone deacetylase 3 (Hdac3) regulates the...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Janardhan, Harish P., Milstone, Zachary J., Shin, Masahiro, Lawson, Nathan D., Keaney, John F., Trivedi, Chinmay M.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663362/
https://ncbi.nlm.nih.gov/pubmed/29035278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92852
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