Neural precursor cell–secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity

In multiple sclerosis, the pathological interaction between autoreactive Th cells and mononuclear phagocytes in the CNS drives initiation and maintenance of chronic neuroinflammation. Here, we found that intrathecal transplantation of neural stem/precursor cells (NPCs) in mice with experimental auto...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: De Feo, Donatella, Merlini, Arianna, Brambilla, Elena, Ottoboni, Linda, Laterza, Cecilia, Menon, Ramesh, Srinivasan, Sundararajan, Farina, Cinthia, Garcia Manteiga, Jose Manuel, Butti, Erica, Bacigaluppi, Marco, Comi, Giancarlo, Greter, Melanie, Martino, Gianvito
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663358/
https://ncbi.nlm.nih.gov/pubmed/28945200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92387
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