Sortilin limits EGFR signaling by promoting its internalization in lung cancer

Tyrosine kinase receptors such as the epidermal growth factor receptor (EGFR) transduce information from the microenvironment into the cell and activate homeostatic signaling pathways. Internalization and degradation of EGFR after ligand binding limits the intensity of proliferative signaling, there...

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Publicado en:Nat Commun
Main Authors: Al-Akhrass, Hussein, Naves, Thomas, Vincent, François, Magnaudeix, Amandine, Durand, Karine, Bertin, François, Melloni, Boris, Jauberteau, Marie-Odile, Lalloué, Fabrice
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662760/
https://ncbi.nlm.nih.gov/pubmed/29084952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01172-5
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