In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer

Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer. Beyond the canonical biosynthetic routes to produce biomass, it is of key importance to focus on metabolic routes that sustain the proliferative ca...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Pey, Jon, San José-Eneriz, Edurne, Ochoa, María Carmen, Apaolaza, Iñigo, de Atauri, Pedro, Rubio, Angel, Cendoya, Xabier, Miranda, Estíbaliz, Garate, Leire, Cascante, Marta, Carracedo, Arkaitz, Agirre, Xabier, Prosper, Felipe, Planes, Francisco J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662602/
https://ncbi.nlm.nih.gov/pubmed/29084986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14067-8
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