In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer

Constraint-based modeling for genome-scale metabolic networks has emerged in the last years as a promising approach to elucidate drug targets in cancer. Beyond the canonical biosynthetic routes to produce biomass, it is of key importance to focus on metabolic routes that sustain the proliferative ca...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pey, Jon, San José-Eneriz, Edurne, Ochoa, María Carmen, Apaolaza, Iñigo, de Atauri, Pedro, Rubio, Angel, Cendoya, Xabier, Miranda, Estíbaliz, Garate, Leire, Cascante, Marta, Carracedo, Arkaitz, Agirre, Xabier, Prosper, Felipe, Planes, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662602/
https://ncbi.nlm.nih.gov/pubmed/29084986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14067-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados