Leishmania infantum lipophosphoglycan induced-Prostaglandin E(2) production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2

Lipophosphoglycan (LPG) is a key virulence factor expressed on the surfaces of Leishmania promastigotes. Although LPG is known to activate macrophages, the underlying mechanisms resulting in the production of prostaglandin E(2) (PGE(2)) via signaling pathways remain unknown. Here, the inflammatory r...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Lima, Jonilson Berlink, Araújo-Santos, Théo, Lázaro-Souza, Milena, Carneiro, Alan Brito, Ibraim, Izabela Coimbra, Jesus-Santos, Flávio Henrique, Luz, Nívea Farias, Pontes, Sara de Moura, Entringer, Petter Franco, Descoteaux, Albert, Bozza, Patrícia Torres, Soares, Rodrigo Pedro, Borges, Valéria Matos
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662570/
https://ncbi.nlm.nih.gov/pubmed/29084985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14229-8
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