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Supercoiling DNA locates mismatches
We present a method of detecting sequence defects by supercoiling DNA with magnetic tweezers. The method is sensitive to a single mismatched base pair in a DNA sequence of several thousand base pairs. We systematically compare DNA molecules with 0 to 16 adjacent mismatches at 1 M monovalent salt and...
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| Publicado no: | Phys Rev Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5661871/ https://ncbi.nlm.nih.gov/pubmed/29053317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1103/PhysRevLett.119.147801 |
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