Epigallocatechin-3-gallate induces apoptosis in acute promyelocytic leukemia cells via a SHP-1-p38α MAPK-Bax cascade

Acute promyelocytic leukemia (APL) is characterized by a specific chromosomal translation, resulting in a fusion gene that affects the differentiation, proliferation and apoptosis of APL cells. Epigallocatechin-3-gallate (EGCG), a catechin, exhibits numerous biological functions, including antitumor...

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Publicat a:Oncol Lett
Autors principals: Gan, Liugen, Zhong, Liang, Shan, Zhiling, Xiao, Chunlan, Xu, Ting, Song, Hao, Li, Liu, Yang, Rong, Liu, Beizhong
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661390/
https://ncbi.nlm.nih.gov/pubmed/29113283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2017.6980
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