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Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide

To examine the in vivo responses of promyelocytic leukemia protein (PML) to arsenic, rats (male, 6 weeks old, Sprague Dawley) were administered a single intraperitoneal dose of 5 mg/kg arsenic trioxide (ATO). The protein was examined in the heart, lung, liver, and brain 6 and 48 hours after administ...

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Bibliographic Details
Published in:J Toxicol Pathol
Main Authors: Watanabe, Ryo, Unuma, Kana, Noritake, Kanako, Funakoshi, Takeshi, Aki, Toshihiko, Uemura, Koichi
Format: Artigo
Language:Inglês
Published: Japanese Society of Toxicologic Pathology 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660956/
https://ncbi.nlm.nih.gov/pubmed/29097844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.2017-0020
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