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Effects of methotrexate exposure on medaka (Oryzias latipes) testes

For the purpose of clarifying the histopathological effects of methotrexate (MTX) on medaka testes, wild-type and homogenic p53-deficient male medaka at 4 to 6 months post-hatching were exposed to 0.25 mg/ml of MTX for 96 h with histopathological examination of testes at 24, 48, 72 and 96 h. At 72 a...

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Bibliografske podrobnosti
izdano v:J Toxicol Pathol
Main Authors: Hirako, Ayano, Takeoka, Yuki, Furukawa, Satoshi, Sugiyama, Akihiko
Format: Artigo
Jezik:Inglês
Izdano: Japanese Society of Toxicologic Pathology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660950/
https://ncbi.nlm.nih.gov/pubmed/29097838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.2017-0029
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