Isotopically nonstationary (13)C flux analysis of cyanobacterial isobutyraldehyde production

We applied isotopically nonstationary (13)C metabolic flux analysis (INST-MFA) to compare the pathway fluxes of wild-type (WT) Synechococcus elongatus PCC 7942 to an engineered strain (SA590) that produces isobutyraldehyde (IBA). The flux maps revealed a potential bottleneck at the pyruvate kinase (...

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Bibliographic Details
Published in:Metab Eng
Main Authors: Jazmin, Lara J., Xu, Yao, Cheah, Yi Ern, Adebiyi, Adeola O., Johnson, Carl Hirschie, Young, Jamey D.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660605/
https://ncbi.nlm.nih.gov/pubmed/28479191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2017.05.001
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