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Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer

Copy-number variations (CNVs) are ubiquitous in cancer and often act as driver events, but the effects of CNVs on the proteome of tumors are poorly understood. Here, we analyze recently published genomics, transcriptomics, and proteomics datasets made available by CPTAC and TCGA consortia on 282 bre...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Gonçalves, Emanuel, Fragoulis, Athanassios, Garcia-Alonso, Luz, Cramer, Thorsten, Saez-Rodriguez, Julio, Beltrao, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660600/
https://ncbi.nlm.nih.gov/pubmed/29032074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2017.08.013
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