Ca(2+) protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity

It is generally accepted that voltage-gated Ca(2+) channels, CaV, regulate Ca(2+) homeostasis in excitable cells following plasma membrane depolarization. Here, we show that the Ca(2+) protein α1D of CaV1.3 channel is overexpressed in colorectal cancer biopsies compared to normal tissues. Gene silen...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fourbon, Yann, Guéguinou, Maxime, Félix, Romain, Constantin, Bruno, Uguen, Arnaud, Fromont, Gaëlle, Lajoie, Laurie, Magaud, Christophe, Lecomte, Thierry, Chamorey, Emmanuel, Chatelier, Aurélien, Mignen, Olivier, Potier-Cartereau, Marie, Chantôme, Aurélie, Bois, Patrick, Vandier, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660277/
https://ncbi.nlm.nih.gov/pubmed/29079724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14230-1
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