SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline

BACKGROUND: Barely 10-20% of patients with metastatic colorectal cancer (mCRC) receive a clinical benefit from the use of anti-EGFR monoclonal antibodies (mAbs). We hypothesized that this could depends on their efficiency to reduce Store Operated Calcium Entry (SOCE) that are known to enhance cancer...

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Publicat a:Oncotarget
Autors principals: Guéguinou, Maxime, Harnois, Thomas, Crottes, David, Uguen, Arnaud, Deliot, Nadine, Gambade, Audrey, Chantôme, Aurélie, Haelters, Jean Pierre, Jaffrès, Paul Alain, Jourdan, Marie Lise, Weber, Günther, Soriani, Olivier, Bougnoux, Philippe, Mignen, Olivier, Bourmeyster, Nicolas, Constantin, Bruno, Lecomte, Thierry, Vandier, Christophe, Potier-Cartereau, Marie
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094991/
https://ncbi.nlm.nih.gov/pubmed/27102434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8786
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