Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43(A315T) ALS/FTD mouse model

Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Previous studies described a TDP-43(A315T) transgenic mouse model that develops pr...

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Publicado en:Sci Rep
Autores principales: Bargsted, Leslie, Medinas, Danilo B., Martínez Traub, Francisca, Rozas, Pablo, Muñoz, Natalia, Nassif, Melissa, Jerez, Carolina, Catenaccio, Alejandra, Court, Felipe A., Hetz, Claudio, Matus, Soledad
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660202/
https://ncbi.nlm.nih.gov/pubmed/29079747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14399-5
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