Glycolipid-peptide conjugate vaccines enhance CD8(+) T cell responses against human viral proteins

An important goal of vaccination against viruses and virus-driven cancers is to elicit cytotoxic CD8(+) T cells specific for virus-derived peptides. CD8(+) T cell responses can be enhanced by engaging help from natural killer T (NKT) cells. We have produced synthetic vaccines that induce strong pept...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Speir, M., Authier-Hall, A., Brooks, C. R., Farrand, K. J., Compton, B. J., Anderson, R. J., Heiser, A., Osmond, T. L., Tang, C. W., Berzofsky, J. A., Terabe, M., Painter, G. F., Hermans, I. F., Weinkove, R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660197/
https://ncbi.nlm.nih.gov/pubmed/29079845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14690-5
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