Development of a Curative Therapeutic Vaccine (TheraVac) for the Treatment of Large Established Tumors

Harnessing immune system to treat cancer requires simultaneous generation of tumor-specific CTLs and curtailment of tumor immunosuppressive environment. Here, we developed an immunotherapeutic regimen capable of eliminating large established mouse tumors using HMGN1, a DC-activating TLR4 agonist cap...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Nie, Yingjie, Yang, De, Trivett, Anna, Han, Zhen, Xin, Haiyun, Chen, Xin, Oppenheim, Joost J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5660153/
https://ncbi.nlm.nih.gov/pubmed/29079801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-14655-8
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