Proteinase activated receptor‐2 counterbalances the vascular effects of endothelin‐1 in fibrotic tight‐skin mice

BACKGROUND AND PURPOSE: The majority of the severe vascular complications in fibrosis are a consequence of a deregulated activity of mediators controlling vasomotor tone. One of the most important of these mediators is endothelin‐1 (ET‐1). Here, we have investigated the role of proteinase‐activated...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Roviezzo, Fiorentina, Brancaleone, Vincenzo, Mattera Iacono, Valentina, Bertolino, Antonio, De Cunto, Giovanna, Vellecco, Valentina, Lungarella, Giuseppe, Lucattelli, Monica, Cirino, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Themed Section: Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659994/
https://ncbi.nlm.nih.gov/pubmed/27625162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13618
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