Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors

Sonic hedgehog (Shh) expression in the limb bud organizing centre called the zone of polarizing activity is regulated by the ZRS enhancer. Here, we examine in mouse and in a mouse limb-derived cell line the dynamic events that activate and restrict the spatial activity of the ZRS. Fibroblast growth...

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Publicat a:eLife
Autors principals: Peluso, Silvia, Douglas, Adam, Hill, Alison, De Angelis, Carlo, Moore, Benjamin L, Grimes, Graeme, Petrovich, Giulia, Essafi, Abdelkader, Hill, Robert E
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Developmental Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659820/
https://ncbi.nlm.nih.gov/pubmed/28949289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28590
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