DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy

BACKGROUND: Fetal exposure to maternal diabetes increases the risk of type 2 diabetes (T2DM), possibly mediated by epigenetic mechanisms. Low blood TXNIP DNA methylation has been associated with elevated glucose levels and risk of T2DM, and increased skeletal muscle TXNIP gene expression was reporte...

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Publicat a:PLoS One
Autors principals: Houshmand-Oeregaard, Azadeh, Hjort, Line, Kelstrup, Louise, Hansen, Ninna S., Broholm, Christa, Gillberg, Linn, Clausen, Tine D., Mathiesen, Elisabeth R., Damm, Peter, Vaag, Allan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659766/
https://ncbi.nlm.nih.gov/pubmed/29077742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187038
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