Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit its Aggregation

Transthyretin (TTR) is a homotetrameric protein. Its dissociation into monomers leads to the formation of fibrils that underlie human amyloidogenic diseases. The binding of small molecules to the thyroxin-binding sites in TTR stabilizes the homotetramer and attenuates TTR amyloidosis. Herein, we rep...

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Udgivet i:J Med Chem
Main Authors: Smith, Thomas P., Windsor, Ian W., Forest, Katrina T., Raines, Ronald T.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659721/
https://ncbi.nlm.nih.gov/pubmed/28920684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00952
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