Subdomain 2, Not the Transmembrane Domain, Determines the Dimerization Partner of Growth Hormone Receptor and Prolactin Receptor

Growth hormone receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane class I cytokine receptors. In humans, GH interacts with GHR homodimers or PRLR homodimers and PRL interacts with only PRLR homodimers to promote signaling. In human breast cancer cells endogenously expres...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Liu, Ying, Jiang, Jing, Lepik, Bradford, Zhang, Yue, Zinn, Kurt R., Frank, Stuart J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2017
Assuntos:
Special Section: Targeting and Regulation of Hormone Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659695/
https://ncbi.nlm.nih.gov/pubmed/28977606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00469
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