Two Wrongs Can Make a Right: Dimers of Prolactin and Growth Hormone Receptor Antagonists Behave as Agonists

Prolactin (PRL) and GH have two distinct binding sites (site 1 with high affinity; site 2 with low affinity) that each interact with a PRL receptor (PRLR) to form a functional receptor dimer that activates signal transduction. The G129R mutation in PRL and the G120R mutation in GH disrupt the struct...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Langenheim, John F., Tan, Dunyong, Walker, Ameae M., Chen, Wen Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1402359/
https://ncbi.nlm.nih.gov/pubmed/16269515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2005-0360
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker