Inhibition of FGFR Signaling Partially Rescues Hypophosphatemic Rickets in HMWFGF2 Tg Male Mice

Transgenic mice harboring high molecular weight fibroblast growth factor (FGF)2 isoforms (HMWTg) in osteoblast lineage cells phenocopy human X-linked hypophosphatemic rickets (XLH) and Hyp murine model of XLH demonstrating increased FGF23/FGF receptor signaling and hypophosphatemic rickets. Because...

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Bibliografske podrobnosti
izdano v:Endocrinology
Main Authors: Xiao, Liping, Du, Erxia, Homer-Bouthiette, Collin, Hurley, Marja M.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2017
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659690/
https://ncbi.nlm.nih.gov/pubmed/28938491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2016-1617
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