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Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

OBJECTIVES: Tamoxifen bioactivation to endoxifen is primarily mediated by CYP2D6; however, substantial variability remains unexplained. Our objective was to conduct a comprehensive assessment of the effect of genetic variation in tamoxifen-relevant enzymes and transporters on steady-state endoxifen...

詳細記述

保存先:
書誌詳細
出版年:Pharmacogenet Genomics
主要な著者: Marcath, Lauren, Deal, Allison M, Van Wieren, Emily, Danko, William, Walko, Christine M, Ibrahim, Joseph G, Weck, Karen E, Jones, David R, Desta, Zeruesenay, McLeod, Howard L, Carey, Lisa A, Irvin, William J, Hertz, Daniel L
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659294/
https://ncbi.nlm.nih.gov/pubmed/28877533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000311
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