Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

OBJECTIVES: Tamoxifen bioactivation to endoxifen is primarily mediated by CYP2D6; however, substantial variability remains unexplained. Our objective was to conduct a comprehensive assessment of the effect of genetic variation in tamoxifen-relevant enzymes and transporters on steady-state endoxifen...

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Publicado en:Pharmacogenet Genomics
Main Authors: Marcath, Lauren, Deal, Allison M, Van Wieren, Emily, Danko, William, Walko, Christine M, Ibrahim, Joseph G, Weck, Karen E, Jones, David R, Desta, Zeruesenay, McLeod, Howard L, Carey, Lisa A, Irvin, William J, Hertz, Daniel L
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659294/
https://ncbi.nlm.nih.gov/pubmed/28877533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000311
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