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Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment
OBJECTIVES: Tamoxifen bioactivation to endoxifen is primarily mediated by CYP2D6; however, substantial variability remains unexplained. Our objective was to conduct a comprehensive assessment of the effect of genetic variation in tamoxifen-relevant enzymes and transporters on steady-state endoxifen...
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| 出版年: | Pharmacogenet Genomics |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5659294/ https://ncbi.nlm.nih.gov/pubmed/28877533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000311 |
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