CRISPR/Cas9-mediated gene editing in human iPSC-derived macrophage reveals lysosomal acid lipase function in human macrophages

OBJECTIVE: To gain mechanistic insights into the role of LIPA, the gene encoding lysosomal acid lipase protein (LAL), in human macrophages. APPROACH AND RESULTS: We used CRISPR/Cas9 technology to knock-out LIPA in human induced pluripotent stem cells (iPSCs), and then differentiate to macrophage (IP...

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Bibliografiske detaljer
Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Zhang, Hanrui, Shi, Jianting, Hachet, Melanie A., Xue, Chenyi, Bauer, Robert C., Jiang, Hongfeng, Li, Wenjun, Tohyama, Junichiro, Millar, John, Billheimer, Jeffrey, Phillips, Michael C., Razani, Babak, Rader, Daniel J., Reilly, Muredach P.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659288/
https://ncbi.nlm.nih.gov/pubmed/28882870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310023
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