Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice

PURPOSE: Methotrexate is widely used in chemotherapy for a variety of malignancies. However, severe toxicity, poor pharmacokinetics, and narrow safety margin of methotrexate limit its clinical application. The aim of this study was to develop sustained-release methotrexate-loaded implants and evalua...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Gao, Li, Xia, Lunyang, Zhang, Ruhui, Duan, Dandan, Liu, Xiuxiu, Xu, Jianjian, Luo, Lan
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2017
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659257/
https://ncbi.nlm.nih.gov/pubmed/29118572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S143942
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