At least 20% donor myeloid chimerism is necessary to reverse the sickle phenotype after allogeneic HSCT

Novel curative therapies using genetic transfer of normal globin-producing genes into autologous hematopoietic stem cells (HSCs) are in clinical trials for patients with sickle cell disease (SCD). The percentage of transferred globin necessary to cure SCD is currently not known. In the setting of al...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Fitzhugh, Courtney D., Cordes, Stefan, Taylor, Tiffani, Coles, Wynona, Roskom, Katherine, Link, Mary, Hsieh, Matthew M., Tisdale, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659067/
https://ncbi.nlm.nih.gov/pubmed/28887325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-772392
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