Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis

Isoprenylcysteine carboxylmethyltransferase (ICMT) catalyzes the post-translational modification of RAB GTPases that contain C-terminal CXC motifs. However, the functional impact of this modification on RAB proteins has not been actively explored. We found that inhibition of ICMT significantly reduc...

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Bibliografiske detaljer
Udgivet i:Oncogene
Main Authors: Do, M T, Chai, T F, Casey, P J, Wang, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658678/
https://ncbi.nlm.nih.gov/pubmed/28604748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.183
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