The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model

Neuronal network dysfunction and cognitive decline constitute the most prominent features of Alzheimer’s disease (AD), although mechanisms causing such impairments are yet to be determined. Here we report that virus-mediated delivery of the active spliced transcription factor X-Box binding protein 1...

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Pubblicato in:Mol Psychiatry
Autori principali: Cissé, M, Duplan, E, Lorivel, T, Dunys, J, Bauer, C, Meckler, X, Gerakis, Y, Lauritzen, I, Checler, F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658671/
https://ncbi.nlm.nih.gov/pubmed/27646263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.152
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