Systemic Gene Delivery Transduces the Enteric Nervous System of Guinea Pigs and Cynomolgus Macaques

Characterization of adeno-associated viral vector (AAV) mediated gene delivery to the enteric nervous system (ENS) was recently described in mice and rats. In these proof-of-concept experiments, we show that intravenous injections of clinically relevant AAVs can transduce the ENS in guinea pigs and...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Gombash, Sara E, Cowley, Christopher J, Fitzgerald, Julie A, Lepak, Christina A, Neides, Mitchell G, Hook, Kathryn, Todd, Levi J, Wang, Guo-Du, Mueller, Christian, Kaspar, Brian K, Bielefeld, Eric C, Fischer, Andrew J, Wood, Jackie D, Foust, Kevin D
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658254/
https://ncbi.nlm.nih.gov/pubmed/28771235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.72
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