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Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast
A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5). These genes encode components of the pre-replication complex, which assembles at origins of replication prior to S phase. Also, variants in...
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| Pubblicato in: | PLoS Genet |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5658192/ https://ncbi.nlm.nih.gov/pubmed/29036220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007041 |
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