Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast

A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5). These genes encode components of the pre-replication complex, which assembles at origins of replication prior to S phase. Also, variants in...

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Gepubliceerd in:PLoS Genet
Hoofdauteurs: Sanchez, Joseph C., Kwan, Elizabeth X., Pohl, Thomas J., Amemiya, Haley M., Raghuraman, M. K., Brewer, Bonita J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658192/
https://ncbi.nlm.nih.gov/pubmed/29036220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007041
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