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Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing

Alpha herpesvirus genomes encode the capacity to establish quiescent infections (i.e. latency) in the peripheral nervous system for the life of their hosts. Multiple times during latency, viral genomes can reactivate to start a productive infection, enabling spread of progeny virions to other hosts....

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Pubblicato in:PLoS Pathog
Autori principali: Koyuncu, Orkide O., MacGibeny, Margaret A., Hogue, Ian B., Enquist, Lynn W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658187/
https://ncbi.nlm.nih.gov/pubmed/29073268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006608
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