Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)

Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain. Cyp46a1(-/-) mice have a reduction in the rate of cholesterol biosynthesis in the brain and significant impairments to memory and learning. To g...

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Bibliographic Details
Published in:PLoS One
Main Authors: Mast, Natalia, Lin, Joseph B., Anderson, Kyle W., Bjorkhem, Ingemar, Pikuleva, Irina A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658173/
https://ncbi.nlm.nih.gov/pubmed/29073233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187168
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