Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation

Hemogenic endothelium (HE) undergoes endothelial-to-hematopoietic transition (EHT) to generate blood, a process that requires progressive down-regulation of endothelial genes and induction of hematopoietic ones. Previously, we have shown that the transcription factor HoxA3 prevents blood formation b...

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Udgivet i:PLoS One
Main Authors: Sanghez, Valentina, Luzzi, Anna, Clarke, Don, Kee, Dustin, Beuder, Steven, Rux, Danielle, Osawa, Mitsujiro, Madrenas, Joaquín, Chou, Tsui-Fen, Kyba, Michael, Iacovino, Michelina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5658089/
https://ncbi.nlm.nih.gov/pubmed/29073173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186818
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