Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Filgotinib, a Selective JAK‐1 Inhibitor, After Short‐Term Treatment of Rheumatoid Arthritis: Results of Two Randomized Phase IIa Trials

OBJECTIVE: JAK inhibitors have shown efficacy in rheumatoid arthritis (RA). We undertook this study to test our hypothesis that selective inhibition of JAK‐1 would combine good efficacy with a better safety profile compared with less selective JAK inhibitors. METHODS: In two 4‐week exploratory, doub...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Vanhoutte, Frédéric, Mazur, Minodora, Voloshyn, Oleksandr, Stanislavchuk, Mykola, Van der Aa, Annegret, Namour, Florence, Galien, René, Meuleners, Luc, van 't Klooster, Gerben
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Rheumatoid Arthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656813/
https://ncbi.nlm.nih.gov/pubmed/28622463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40186
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