Clonal Heterogeneity Influences the Fate of New Adaptive Mutations

The joint contribution of pre-existing and de novo genetic variation to clonal adaptation is poorly understood but essential to designing successful antimicrobial or cancer therapies. To address this, we evolve genetically diverse populations of budding yeast, S. cerevisiae, consisting of diploid ce...

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Vydáno v:Cell Rep
Hlavní autoři: Vázquez-García, Ignacio, Salinas, Francisco, Li, Jing, Fischer, Andrej, Barré, Benjamin, Hallin, Johan, Bergström, Anders, Alonso-Perez, Elisa, Warringer, Jonas, Mustonen, Ville, Liti, Gianni
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656752/
https://ncbi.nlm.nih.gov/pubmed/29045840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.046
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